4H,5H,6H,7H-thieno[3,2-c]pyridine-5-carbonyl chloride → 1-(6,7-Dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl)-6-fluoro-1H-indazol-3-yl 6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate

HRID 501477Notes

Reaction equation

HRID 501477 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([OH:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[S:12]1[C:20]2[CH2:19][CH2:18][N:17]([C:21](Cl)=[O:22])[CH2:16][C:15]=2[CH:14]=[CH:13]1>>[S:12]1[C:20]2[CH2:19][CH2:18][N:17]([C:21]([O:11][C:6]3[C:5]4[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=4)[N:8]([C:21]([N:17]4[CH2:18][CH2:19][C:20]5[S:12][CH:13]=[CH:14][C:15]=5[CH2:16]4)=[O:22])[N:7]=3)=[O:22])[CH2:16][C:15]=2[CH:14]=[CH:13]1

Participants

3

Reactant 2

HCID 798874294H,5H,6H,7H-thieno[3,2-c]pyridine-5-carbonyl chlorideHCID 178518961HCID 178518961, compound

Product 1

HCID 684570761-(6,7-Dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl)-6-fluoro-1H-indazol-3-yl 6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carboxylate

Procedure

In analogy to example 1, 200 mg (1.315 mmol) of 6-fluoro-1H-indazol-3-ol were reacted with 318 mg (1.578 mmol) of 6,7-dihydro-4H-thieno[3,2-c]pyridine-5-carbonyl chloride. Yield: 18 mg (3%), M+H+: 483.25.

Sources & evidence

ORD record
ord-fcdf01963ec94b3b89753f2ea04b5fba
Source dataset
uspto-grants-2010_08
Patent number
US07772268B2

Reaction notes

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