Thiomorpholine-4-carbonyl chloride → 6-Fluoro-1-(thiomorpholine-4-carbonyl)-1H-indazol-3-yl thiomorpholine-4-carboxylate

HRID 501478Notes

Reaction equation

HRID 501478 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([OH:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[N:12]1([C:18](Cl)=[O:19])[CH2:17][CH2:16][S:15][CH2:14][CH2:13]1>>[N:12]1([C:18]([O:11][C:6]2[C:5]3[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=3)[N:8]([C:18]([N:12]3[CH2:17][CH2:16][S:15][CH2:14][CH2:13]3)=[O:19])[N:7]=2)=[O:19])[CH2:17][CH2:16][S:15][CH2:14][CH2:13]1

Participants

3

Reactant 2

HCID 19080217Thiomorpholine-4-carbonyl chlorideHCID 178518961HCID 178518961, compound

Product 1

HCID 684595896-Fluoro-1-(thiomorpholine-4-carbonyl)-1H-indazol-3-yl thiomorpholine-4-carboxylate

Procedure

In analogy to example 1, 200 mg (1.315 mmol) of 6-fluoro-1H-indazol-3-ol were reacted with 261.4 mg (1.578 mmol) of thiomorpholine-4-carbonyl chloride. Yield: 39 mg (7%), M+H+: 411.17.

Sources & evidence

ORD record
ord-e2b12b0309124e0a8e5f15bd285ee800
Source dataset
uspto-grants-2010_08
Patent number
US07772268B2

Reaction notes

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