4-(Trifluoromethyl)piperidine-1-carbonyl chloride → 6-Fluoro-1-(4-trifluoromethylpiperidine-1-carbonyl)-1H-indazol-3-yl 4-trifluoromethylpiperidine-1-carboxylate

HRID 501479Notes

Reaction equation

HRID 501479 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([OH:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[F:12][C:13]([F:24])([F:23])[CH:14]1[CH2:19][CH2:18][N:17]([C:20](Cl)=[O:21])[CH2:16][CH2:15]1>>[F:12][C:13]([F:24])([F:23])[CH:14]1[CH2:19][CH2:18][N:17]([C:20]([O:11][C:6]2[C:5]3[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=3)[N:8]([C:20]([N:17]3[CH2:16][CH2:15][CH:14]([C:13]([F:23])([F:12])[F:24])[CH2:19][CH2:18]3)=[O:21])[N:7]=2)=[O:21])[CH2:16][CH2:15]1

Participants

3

Reactant 2

HCID 798870814-(Trifluoromethyl)piperidine-1-carbonyl chlorideHCID 178518961HCID 178518961, compound

Product 1

HCID 866248206-Fluoro-1-(4-trifluoromethylpiperidine-1-carbonyl)-1H-indazol-3-yl 4-trifluoromethylpiperidine-1-carboxylate

Procedure

In analogy to example 1, 200 mg (1.315 mmol) of 6-fluoro-1H-indazol-3-ol were reacted with 340 mg (1.578 mmol) of 4-trifluoromethylpiperidine-1-carbonyl chloride. Yield: 8 mg (1%), M+H+: 511.36.

Sources & evidence

ORD record
ord-83035950052b4f24a61b682402deb4ea
Source dataset
uspto-grants-2010_08
Patent number
US07772268B2

Reaction notes

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