2,6-Dimethylmorpholine-4-carbonyl chloride → 1-(2,6-Dimethylmorpholine-4-carbonyl)-6-fluoro-1H-indazol-3-yl 2,6-dimethylmorpholine-4-carboxylate

HRID 501480Notes

Reaction equation

HRID 501480 reaction equation
[F:1][C:2]1[CH:10]=[C:9]2[C:5]([C:6]([OH:11])=[N:7][NH:8]2)=[CH:4][CH:3]=1.[CH3:12][CH:13]1[O:18][CH:17]([CH3:19])[CH2:16][N:15]([C:20](Cl)=[O:21])[CH2:14]1>>[CH3:12][CH:13]1[O:18][CH:17]([CH3:19])[CH2:16][N:15]([C:20]([O:11][C:6]2[C:5]3[C:9](=[CH:10][C:2]([F:1])=[CH:3][CH:4]=3)[N:8]([C:20]([N:15]3[CH2:16][CH:17]([CH3:19])[O:18][CH:13]([CH3:12])[CH2:14]3)=[O:21])[N:7]=2)=[O:21])[CH2:14]1

Participants

3

Reactant 2

HCID 190802282,6-Dimethylmorpholine-4-carbonyl chlorideHCID 178518961HCID 178518961, compound

Product 1

HCID 684554181-(2,6-Dimethylmorpholine-4-carbonyl)-6-fluoro-1H-indazol-3-yl 2,6-dimethylmorpholine-4-carboxylate

Procedure

In analogy to example 1, 200 mg (1.315 mmol) of 6-fluoro-1H-indazol-3-ol were reacted with 280.3 mg (1.578 mmol) of 2,6-dimethylmorpholine-4-carbonyl chloride. Yield: 16 mg (3%), M+H+: 435.29.

Sources & evidence

ORD record
ord-e8daa9859f814734875d0d044582f137
Source dataset
uspto-grants-2010_08
Patent number
US07772268B2

Reaction notes

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