6-Amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate → 6-Amino-1-(4-trifluoromethylpiperidine-1-carbonyl)-1H-indazol-3-yl 4-methyl-piperidine-1-carboxylate

HRID 501486Notes

Reaction equation

HRID 501486 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([NH2:20])=[CH:17][CH:18]=3)[NH:13][N:12]=2)=[O:9])[CH2:4][CH2:3]1.[F:21][C:22]([F:33])([F:32])[CH:23]1[CH2:28][CH2:27][N:26]([C:29](Cl)=[O:30])[CH2:25][CH2:24]1>>[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]2[C:19]3[C:14](=[CH:15][C:16]([NH2:20])=[CH:17][CH:18]=3)[N:13]([C:29]([N:26]3[CH2:25][CH2:24][CH:23]([C:22]([F:32])([F:21])[F:33])[CH2:28][CH2:27]3)=[O:30])[N:12]=2)=[O:9])[CH2:4][CH2:3]1

Participants

3

Reactant 2

HCID 115073446-Amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylateHCID 798870814-(Trifluoromethyl)piperidine-1-carbonyl chloride

Product 1

HCID 684598656-Amino-1-(4-trifluoromethylpiperidine-1-carbonyl)-1H-indazol-3-yl 4-methyl-piperidine-1-carboxylate

Procedure

In analogy to example 12, 35.66 mg (0.13 mmol) of 6-amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate were reacted with 33.63 mg (0.16 mmol) of 4-trifluoromethylpiperidine-1-carbonyl chloride. Yield: 10 mg (17%), M+H+: 454.13.

Sources & evidence

ORD record
ord-e574b8270b514c8c81e87a09f304cbe1
Source dataset
uspto-grants-2010_08
Patent number
US07772268B2

Reaction notes

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