HuagongsheHuagongshe Chemistry Print Report · For research reference only
6-Amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate → 6-Amino-1-(4-trifluoromethylpiperidine-1-carbonyl)-1H-indazol-3-yl 4-methyl-piperidine-1-carboxylate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 6-Amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate | HCID 11507344 | — |
| Reactant | 4-(Trifluoromethyl)piperidine-1-carbonyl chloride | HCID 79887081 | — |
| Product | 6-Amino-1-(4-trifluoromethylpiperidine-1-carbonyl)-1H-indazol-3-yl 4-methyl-piperidine-1-carboxylate | HCID 68459865 | — |
Reaction Steps
In analogy to example 12, 35.66 mg (0.13 mmol) of 6-amino-1H-indazol-3-yl 4-methylpiperidine-1-carboxylate were reacted with 33.63 mg (0.16 mmol) of 4-trifluoromethylpiperidine-1-carbonyl chloride. Yield: 10 mg (17%), M+H+: 454.13.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772268B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-e574b8270b514c8c81e87a09f304cbe1 |
| Source note | uspto-grants-2010_08 |