4-(Trifluoromethyl)piperidine-1-carbonyl chloride → HCID 178429196, compound

HRID 501487Notes

Reaction equation

HRID 501487 reaction equation
[CH3:1][CH:2]1[CH2:7][CH2:6][N:5]([C:8]([O:10][C:11]2[C:19]3[C:14](=[N:15][C:16]([OH:21])=[CH:17][C:18]=3[CH3:20])[NH:13][N:12]=2)=[O:9])[CH2:4][CH2:3]1.[F:22][C:23]([F:34])([F:33])[CH:24]1[CH2:29][CH2:28][N:27]([C:30](Cl)=[O:31])[CH2:26][CH2:25]1>>[CH3:1][CH:2]1[CH2:3][CH2:4][N:5]([C:8]([O:10][C:11]2[C:19]3[C:14](=[N:15][C:16]([OH:21])=[CH:17][C:18]=3[CH3:20])[N:13]([C:30]([N:27]3[CH2:26][CH2:25][CH:24]([C:23]([F:33])([F:22])[F:34])[CH2:29][CH2:28]3)=[O:31])[N:12]=2)=[O:9])[CH2:6][CH2:7]1

Participants

3

Reactant 2

HCID 798870814-(Trifluoromethyl)piperidine-1-carbonyl chlorideHCID 178429276HCID 178429276, compound

Product 1

HCID 178429196HCID 178429196, compound

Procedure

In analogy to example 12, 99.87 mg (0.344 mmol) of 6-hydroxy-4-methyl-1H-pyrazolo[3,4-b]pyridin-3-yl 4-methylpiperidine-1-carboxylate were reacted with 83.4 mg (0.52 mmol) of 4-trifluoromethylpiperidine-1-carbonyl chloride. Yield: 16 mg (10%), M+H+: 470.20.

Sources & evidence

ORD record
ord-7abd77339cf14448ad2a3f785a3d3f8b
Source dataset
uspto-grants-2010_08
Patent number
US07772268B2

Reaction notes

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