Pyridine → HCID 68457290, compound

HRID 501493Notes

Reaction equation

[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:13]=[CH:12][C:11]([S:14]([N:17]3[CH:21]([C:22]([OH:24])=[O:23])[CH2:20][CH:19]4[CH2:25][CH2:26][CH2:27][CH:18]34)(=[O:16])=[O:15])=[CH:10][CH:9]=2)=[CH:4][CH:3]=1.N1C=CC=CC=1.Cl[C:35]([O:37][CH:38]([CH3:40])[CH3:39])=[O:36]>CN(C=O)C>[CH:38]([O:37][C:35]([NH:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[CH:9]=[CH:10][C:11]([S:14]([N:17]3[CH:21]([C:22]([OH:24])=[O:23])[CH2:20][CH:19]4[CH2:25][CH2:26][CH2:27][CH:18]34)(=[O:16])=[O:15])=[CH:12][CH:13]=2)=[CH:4][CH:3]=1)=[O:36])([CH3:40])[CH3:39]

Participants

Conditions

Temperature: 0 °C

Procedure

500 mg (1.30 mmol) of 1-(4′-aminobiphenyl-4-sulfonyl)octahydrocyclopenta[b]pyrrole-2-carboxylic acid were dissolved in 3 ml of DMF, after which the solution was cooled down to 0° C. in an ice bath and 2.6 mmol of pyridine were added. After the mixture had been stirred at 0° C. for 15 min, 2 mmol of isopropyl chloroformate in 3 ml of DMF were added. The reaction solution was then stirred at RT for a further 2 h. The crude product was purified using chromatographic methods.

Workup

stirringThe reaction solution was then stirred at RT for a further 2 h
customThe crude product was purified

Sources & evidence

ORD record: ord-2f254e9daf0e4101ba25437990f26826
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07772270B2

Reaction notes

Loading…