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Hydrogen chloride gas was bubbled through a suspension of trans-3-hydroxy-L-proline (50 g, 0.38 mol) in MeOH (600 mL) cooled to 0° C. for 10 min. The resulting clear solution was stirred at rt for 4 h, then concentrated carefully under reduced pressure (white precipitates formed during the concentration). The resulting white solid was dried under vacuum overnight to afford the title compound (68.26 g) as a white solid.

1. concentrationconcentrated carefully under reduced pressure (
2. customwhite precipitates
3. customformed during the concentration)
4. customThe resulting white solid was dried under vacuum overnight