反应详情

温度

0 °C

To a stirring suspension of compound 2D (0.10 g, 0.48 mmol) and NaHCO3 (0.404 g, 4.80 mmol) in CH2Cl2 (4 mL) cooled to 0° C. was rapidly added a solution of phosgene (20%) in toluene (0.95 mL, 4.32 mmol). After addition, the mixture was stirred at rt for 2 h, then filtered to remove the solid. The filtrate was concentrated under reduced pressure, the resulting solid residue dried under vacuum for 1 h to afford compound 2E (95 mg) as a light yellow solid.

1. additionAfter addition
2. filtrationfiltered
3. customto remove the solid
4. concentrationThe filtrate was concentrated under reduced pressure
5. customthe resulting solid residue dried under vacuum for 1 h