Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Triethyl orthoacetate → 7-Cyano-2-methyl-4-nitrobenzoxazole
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Triethyl orthoacetate | HCID 66221 | — |
| 반응물 | Benzenesulfonic acid, 4-methyl-, compd. with pyridine (1:1) | HCID 466102 | — |
| 반응물 | 2-Amino-4-cyano-3-hydroxynitrobenzene | HCID 21875462 | — |
| 용매 | O-Xylene | HCID 7237 | — |
| 생성물 | 7-Cyano-2-methyl-4-nitrobenzoxazole | HCID 21875286 | 70.3% |
반응 단계
To a solution of 11A (0.2 g, 1.12 mmol) in xylene (6 mL) was added triethyl orthoacetate (0.62 mL, 3.35 mmol) and pyridinium p-toluenesulfonate (0.04 g, 1.12 mmol). The mixture was refluxed for 3 h, then allowed to cool to rt and partitioned between H2O and EtOAc. The separated EtOAc layer was concentrated under reduced pressure and the residue was chromatographed eluting with 20% EtOAc in hexane to afford compound 11B (0.16 g) as a solid.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772267B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-5be70b5d4cdb47a2a587418cdca47843 |
| 출처 메모 | uspto-grants-2010_08 |