反应详情

To a solution of 11A (0.2 g, 1.12 mmol) in xylene (6 mL) was added triethyl orthoacetate (0.62 mL, 3.35 mmol) and pyridinium p-toluenesulfonate (0.04 g, 1.12 mmol). The mixture was refluxed for 3 h, then allowed to cool to rt and partitioned between H2O and EtOAc. The separated EtOAc layer was concentrated under reduced pressure and the residue was chromatographed eluting with 20% EtOAc in hexane to afford compound 11B (0.16 g) as a solid.

1. temperatureThe mixture was refluxed for 3 h
2. custompartitioned between H2O and EtOAc
3. concentrationThe separated EtOAc layer was concentrated under reduced pressure
4. customthe residue was chromatographed
5. washeluting with 20% EtOAc in hexane