反应详情

Compound 46B (50 mg, 0.26 mmol) was dissolved in DMF (1 mL), CsF (120 mg, 0.79 mmol) and benzyl chloride (0.09 mL, 0.79 mmol) were added, and the reaction was stirred at rt for 16 h. The reaction mixture was then concentrated under reduced pressure and subsequently purified by silica gel flash chromatography eluting with 0-5% EtOAc/CH2Cl2 (gradient) to give the title compound (57 mg, 77%). LC/MS m/z 281 [M+H]+.

1. concentrationThe reaction mixture was then concentrated under reduced pressure
2. customsubsequently purified by silica gel flash chromatography
3. washeluting with 0-5% EtOAc/CH2Cl2 (gradient)