Potassium Carbonate → HCID 68460862, compound

HRID 501704Notes

Reaction equation

HRID 501704 reaction equation
[CH2:1]([O:4][C@H:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:14][CH3:15])=[CH:10][CH:11]=2)[C@H:6]1[NH:16]C(=O)C(F)(F)F)[CH:2]=[CH2:3].C(=O)([O-])[O-].[K+].[K+]>CO>[CH2:1]([O:4][C@H:5]1[CH2:13][C:12]2[C:7](=[CH:8][C:9]([O:14][CH3:15])=[CH:10][CH:11]=2)[C@H:6]1[NH2:16])[CH:2]=[CH2:3]

Participants

4

Reactant 2

HCID 11430Potassium CarbonateHCID 86622336HCID 86622336, compound

Product 1

HCID 68460862HCID 68460862, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Conditions

Temperature
73 °C

Procedure

Step AE (3): N-((1R,2S)-2-(allyloxy)-6-methoxy-2,3-dihydro-1H-inden-1-yl)-2,2,2-trifluoroacetamide (650 mg) in methanol (15 mL) was added saturated potassium carbonate (570 mg), and the resulting solution was heated at 73° C. for 12 h. The reaction mixture was filtered through a pad of Celite to give, and the filtrate was evaporated in vacuo to give (1R,2S)-2-(allyloxy)-6-methoxy-2,3-dihydro-1H-inden-1-amine as a solid. HPLC Retention time: 1.34 min (method B). MS (ESI) (M+H)+ 220.27.

Workup

  1. filtrationThe reaction mixture was filtered through a pad of Celite
  2. customto give
  3. customthe filtrate was evaporated in vacuo

Sources & evidence

ORD record
ord-733e662ea1724acb8868f9672b80a2b5
Source dataset
uspto-grants-2010_08
Patent number
US07772221B2

Reaction notes

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