Trifluoroacetic acid → HCID 70267100, compound

HRID 501757Notes

Reaction equation

[CH2:1]([C@H:8]1[C@H:29]([OH:30])[CH2:28][NH:27][C@H:26]2[C@H:18]([CH2:19][C:20]3[CH:21]=[CH:22][C:23]([O:31][CH3:32])=[CH:24][C:25]=32)OC[CH2:15][CH2:14][CH2:13][CH2:12][C@H:11]([N:33]([CH3:43])[S:34]([CH2:37][CH2:38][C:39]([F:42])([F:41])[F:40])(=[O:36])=[O:35])[C:10](=[O:44])[NH:9]1)[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[C:45](O)(C(F)(F)F)=[O:46]>>[CH2:1]([C@@H:8]1[NH:9][C:10](=[O:44])[C@@H:11]([N:33]([CH3:43])[S:34]([CH2:37][CH2:38][C:39]([F:42])([F:40])[F:41])(=[O:35])=[O:36])[CH2:12][CH:13]=[CH:14][CH2:15][O:46][CH2:45][C@@H:19]2[CH2:18][C@@H:26]([C:21]3[CH:22]=[C:23]([O:31][CH3:32])[CH:24]=[CH:25][C:20]=32)[NH:27][CH2:28][C@H:29]1[OH:30])[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

Reactant 2

HCID 6422Trifluoroacetic acid

HCID 59423807HCID 59423807, compound

Product 1

HCID 70267100HCID 70267100, compound

Procedure

Step DE (3): The product isomers A and B from Step DE (2) were individually converted to isomers A and B of the TFA salts of the title compound (4 mg of isomer A, and 4 mg of isomer B, colorless oils) by a procedure analogous to Step CX (3). Data for isomer A: LC-MS Rt 1.70 min (method A), (M+H)+ 614.16. Data for isomer B: LC-MS Rt 1.71 min (method A), (M+H)+ 614.30.

Sources & evidence

ORD record: ord-985c2443c31944f1be1a008c120ed527
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07772221B2

Reaction notes

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