HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-(3-Chloro-phenyl)-6-[hydroxy-(3-methyl-3h-imidazol-4-yl)-quinolin-3-yl-methyl]-1h-quinolin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | HCID 21186408 | HCID 21186408 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | 4-(3-Chloro-phenyl)-6-[hydroxy-(3-methyl-3h-imidazol-4-yl)-quinolin-3-yl-methyl]-1h-quinolin-2-one | HCID 22465417 | — |
Reaction Steps
Following the same procedure as described in Example 1F, the title compound of 38A (81 mg, 0.16 mmol) was treated with HCl in aqueous THF to yield the title compound of example 38B (56.4 mg, 71% yield).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710209B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-b84c705fa61e49c4b685f85870674568 |
| Source note | uspto-grants-2004_03 |