Hydrochloric Acid → 4-(3-Chloro-phenyl)-6-[hydroxy-(3-methyl-3h-imidazol-4-yl)-quinolin-3-yl-methyl]-1h-quinolin-2-one

HRID 50179Notes

Reaction equation

HRID 50179 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([C:30]4[N:31]([CH3:35])[CH:32]=[N:33][CH:34]=4)([C:20]4[CH:21]=[N:22][C:23]5[C:28]([CH:29]=4)=[CH:27][CH:26]=[CH:25][CH:24]=5)[OH:19])[CH:16]=3)[N:11]=[C:10]([O:36]C)[CH:9]=2)[CH:5]=[CH:6][CH:7]=1.Cl>C1COCC1>[Cl:1][C:2]1[CH:3]=[C:4]([C:8]2[C:17]3[C:12](=[CH:13][CH:14]=[C:15]([C:18]([OH:19])([C:30]4[N:31]([CH3:35])[CH:32]=[N:33][CH:34]=4)[C:20]4[CH:21]=[N:22][C:23]5[C:28]([CH:29]=4)=[CH:27][CH:26]=[CH:25][CH:24]=5)[CH:16]=3)[NH:11][C:10](=[O:36])[CH:9]=2)[CH:5]=[CH:6][CH:7]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 21186408HCID 21186408, compound

Product 1

HCID 224654174-(3-Chloro-phenyl)-6-[hydroxy-(3-methyl-3h-imidazol-4-yl)-quinolin-3-yl-methyl]-1h-quinolin-2-one

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

Following the same procedure as described in Example 1F, the title compound of 38A (81 mg, 0.16 mmol) was treated with HCl in aqueous THF to yield the title compound of example 38B (56.4 mg, 71% yield).

Sources & evidence

ORD record
ord-b84c705fa61e49c4b685f85870674568
Source dataset
uspto-grants-2004_03
Patent number
US06710209B2

Reaction notes

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