反应详情

6-(4-nitrophenoxy)-hexanoic acid methyl ester 21 (125 g, 468.16 mmol) was refluxed in conc. HCl (1250 ml) for 16 hours. The reaction mixture was cooled to room temp., filtered, dried and recrystallised from a mixture of ethyl acetate:hexane (1:6) to get pure 35 (95 g, 80.2%) as a white powder with an m.p. between 104-107° C.

1. temperatureThe reaction mixture was cooled to room temp.
2. filtrationfiltered
3. customdried
4. customrecrystallised from a mixture of ethyl acetate:hexane (1:6)