6-Bromo-4-(3-chlorophenyl)-2-methoxyquinoline → [4-(3-chloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-methyl-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanol

HRID 50188Notes

Reaction equation

HRID 50188 reaction equation
Br[C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[N:8]=[C:7]([O:12][CH3:13])[CH:6]=[C:5]2[C:14]1[CH:19]=[CH:18][CH:17]=[C:16]([Cl:20])[CH:15]=1.[CH3:21][C:22]1[N:27]=[CH:26][C:25]([C:28]([C:30]2[N:31]([CH3:35])[CH:32]=[N:33][CH:34]=2)=[O:29])=[CH:24][CH:23]=1>>[Cl:20][C:16]1[CH:15]=[C:14]([C:5]2[C:4]3[C:9](=[CH:10][CH:11]=[C:2]([C:28]([C:25]4[CH:26]=[N:27][C:22]([CH3:21])=[CH:23][CH:24]=4)([C:30]4[N:31]([CH3:35])[CH:32]=[N:33][CH:34]=4)[OH:29])[CH:3]=3)[N:8]=[C:7]([O:12][CH3:13])[CH:6]=2)[CH:19]=[CH:18][CH:17]=1

Participants

3

Reactant 2

HCID 120166726-Bromo-4-(3-chlorophenyl)-2-methoxyquinolineHCID 224654472-methyl-5-(1-methyl-1H-imidazole-5-carbonyl)pyridine

Product 1

HCID 18404110[4-(3-chloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-methyl-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanolYield 48%

Procedure

Following the same procedure as that described in Example 1E, 6-bromo-4-(3-chloro-phenyl)-2-methoxy-quinoline (0.200 g, 0.574 mmol) and (6-methyl-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanone (0.105 g, 0.522 mmol) generated 0.118 g (48% yield) of [4-(3-chloro-phenyl)-2-methoxy-quinolin-6-yl]-(6-methyl-pyridin-3-yl)-(3-methyl-3H-imidazol-4-yl)-methanol.

Sources & evidence

ORD record
ord-e1bffb28eceb4bcd9fcdf52f342a3580
Source dataset
uspto-grants-2004_03
Patent number
US06710209B2

Reaction notes

Loading…