참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|
| 반응물 | Ethylenediaminetetraacetic Acid | HCID 6049 | — |
| 반응물 | Sodium Hydroxide | HCID 14798 | — |
| 반응물 | N-(3-(3-(Dimethylamino)-1-oxo-2-propenyl)phenyl)-N-ethylacetamide | HCID 53395302 | — |
| 반응물 | HCID 178510443 | HCID 178510443 | — |
| 용매 | Water | HCID 962 | — |
| 생성물 | Zaleplon | HCID 5719 | — |
반응 단계
2.0 gm N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethyl acetamide was added to a slurry of 40 ml water containing 0.83 gm of 3-amino-4-cyanopyrazole and 6.0 gm edetic acid. The reaction mass was heated to 60° C. for 3 hrs. After cooling the reaction mixture to 20° C., 15% aqueous sodium hydroxide solution was added and the pH of the reaction mixture was adjusted to between 9-10. The reaction mass was stirred for 1 hr. and filtered to give the title compound.
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|
| 특허 번호 | US07772394B2 |
|---|
| 출처 데이터셋 | uspto-grants-2010_08 |
|---|
| ORD ID | ord-3e3fef53901d47a7a61c5037187b1682 |
|---|
| 출처 메모 | uspto-grants-2010_08 |
|---|
