Ethylenediaminetetraacetic Acid → Zaleplon

HRID 501880Notizen

Reaktionsgleichung

Reaktionsgleichung von HRID 501880
C[N:2]([CH3:19])[CH:3]=[CH:4][C:5]([C:7]1[CH:8]=[C:9]([N:13]([CH2:17][CH3:18])[C:14](=[O:16])[CH3:15])[CH:10]=[CH:11][CH:12]=1)=O.N[C:21]1[C:25]([C:26]#[N:27])=C[NH:23][N:22]=1.C(CN(CC(O)=O)CC(O)=O)N(CC(O)=O)CC(O)=O.[OH-].[Na+]>O>[C:26]([C:25]1[CH:21]=[N:22][N:23]2[C:5]([C:7]3[CH:8]=[C:9]([N:13]([CH2:17][CH3:18])[C:14](=[O:16])[CH3:15])[CH:10]=[CH:11][CH:12]=3)=[CH:4][CH:3]=[N:2][C:19]=12)#[N:27]

Komponenten

6

Edukt 4

HCID 6049Ethylenediaminetetraacetic AcidHCID 14798Sodium HydroxideHCID 53395302N-(3-(3-(Dimethylamino)-1-oxo-2-propenyl)phenyl)-N-ethylacetamideHCID 178510443HCID 178510443, Verbindung

Produkt 1

HCID 5719Zaleplon

Reagenzien, Katalysatoren, Lösungsmittel 1

HCID 962WaterLösungsmittel

Reaktionsbedingungen

Temperatur
60 °C

Versuchsvorschrift

2.0 gm N-[3-[3-(Dimethylamino)-1-oxo-2-propenyl]phenyl]-N-ethyl acetamide was added to a slurry of 40 ml water containing 0.83 gm of 3-amino-4-cyanopyrazole and 6.0 gm edetic acid. The reaction mass was heated to 60° C. for 3 hrs. After cooling the reaction mixture to 20° C., 15% aqueous sodium hydroxide solution was added and the pH of the reaction mixture was adjusted to between 9-10. The reaction mass was stirred for 1 hr. and filtered to give the title compound.

Aufarbeitung

  1. temperatureAfter cooling the reaction mixture to 20° C.
  2. filtrationand filtered

Quellen und Nachweise

ORD-Eintrag
ord-3e3fef53901d47a7a61c5037187b1682
Quelldatensatz
uspto-grants-2010_08
Patentnummer
US07772394B2

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