HuagongsheHuagongshe Chemistry Print Report · For research reference only
Isobutylamine → (1-Benzyl-2-hydroxy-3-isobutylaminopropyl)carbamic acid tert-butyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Isobutylamine | HCID 6558 | — |
| Reactant | tert-Butyl (1-(oxiran-2-yl)-2-phenylethyl)carbamate | HCID 4571240 | — |
| Product | (1-Benzyl-2-hydroxy-3-isobutylaminopropyl)carbamic acid tert-butyl ester | HCID 21878363 | — |
Reaction Steps
To 154.4 Kg isobutylamine, (1-Oxiranyl-2-phenyl-ethyl)-carbamic acid tert-butyl ester (53.3 Kg) was added, and then the solution was heated under reflux. Under reduced pressure, isobutylamine was removed from the reaction mixture, and then replaced by toluene.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772411B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-49ad5ce2727446fe9f43cc99acc16152 |
| Source note | uspto-grants-2010_08 |