HuagongsheHuagongshe Chemistry Print Report · For research reference only
Epichlorohydrin → 4-Benzyloxy-1-(2,3-epoxypropoxy)-2-fluorobenzene
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Epichlorohydrin | HCID 7835 | — |
| Reactant | Piperidine | HCID 8082 | — |
| Reactant | Phenol, 2-fluoro-4-(phenylmethoxy)- | HCID 13578007 | — |
| Product | 4-Benzyloxy-1-(2,3-epoxypropoxy)-2-fluorobenzene | HCID 19797582 | — |
Reaction Steps
4.0 g of 4-benzyloxy-2-fluorophenol is reacted with 10 g epichlorhydrin and 0.2 ml piperidine for 90 minutes at 100°. After removal of the volatile material, 40 ml tetrahydrofuran and 20 ml 2M NaOH is added. After 1 hour stirring the solvent is evaporated and the residue partitioned between methylenechloride and water. The organic phase is purified over silica gel with toluene giving 4-benzyloxy-1-(2,3-epoxypropoxy)-2-fluorobenzene (colourless oil).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05242943 |
| Source dataset | uspto-grants-1993_09 |
| ORD ID | ord-3f1ba7546b9c42598686538126fd8e3a |
| Source note | uspto-grants-1993_09 |