反应详情

4.0 g of 4-benzyloxy-2-fluorophenol is reacted with 10 g epichlorhydrin and 0.2 ml piperidine for 90 minutes at 100°. After removal of the volatile material, 40 ml tetrahydrofuran and 20 ml 2M NaOH is added. After 1 hour stirring the solvent is evaporated and the residue partitioned between methylenechloride and water. The organic phase is purified over silica gel with toluene giving 4-benzyloxy-1-(2,3-epoxypropoxy)-2-fluorobenzene (colourless oil).

1. customAfter removal of the volatile material, 40 ml tetrahydrofuran and 20 ml 2M NaOH
2. additionis added
3. customis evaporated
4. customthe residue partitioned between methylenechloride and water
5. customThe organic phase is purified over silica gel with toluene