1-Methylpiperazine → HCID 22636123, compound

HRID 502053Notes

Reaction equation

[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([NH:8][C:9]2[CH:14]=[C:13]([N:15]3[CH2:20][CH2:19][O:18][CH2:17][CH2:16]3)[CH:12]=[C:11]([F:21])[CH:10]=2)=[O:7])=[CH:4][C:3]=1[NH:24][C:25]([C:27]1[CH:28]=[N:29][C:30](Cl)=[CH:31][CH:32]=1)=[O:26].[CH3:34][N:35]1[CH2:40][CH2:39][NH:38][CH2:37][CH2:36]1>O>[Cl:1][C:2]1[CH:23]=[CH:22][C:5]([C:6]([NH:8][C:9]2[CH:14]=[C:13]([N:15]3[CH2:16][CH2:17][O:18][CH2:19][CH2:20]3)[CH:12]=[C:11]([F:21])[CH:10]=2)=[O:7])=[CH:4][C:3]=1[NH:24][C:25]([C:27]1[CH:28]=[N:29][C:30]([N:38]2[CH2:39][CH2:40][N:35]([CH3:34])[CH2:36][CH2:37]2)=[CH:31][CH:32]=1)=[O:26]

Participants

Conditions

Temperature: 110 °C

Procedure

A mixture of 4-chloro-3-(6-chloropyrid-3-ylcarbonylamino)-N-(3-fluoro-5-morpholinophenyl)benzamide (0.2 g) and N-methylpiperazine (1.5 g) was stirred and heated to 110° C. for 20 hours. The mixture was cooled to ambient temperature. Water was added and the mixture was stirred at ambient temperature for 30 minutes. The resultant precipitate was isolated, washed with water and dried. There was thus obtained the title compound (0.18 g); Mass Spectrum: M+H+ 553.

Workup

temperatureThe mixture was cooled to ambient temperature
stirringthe mixture was stirred at ambient temperature for 30 minutes

Sources & evidence

ORD record: ord-4824677b30e444b7827acd5ef2d1a595
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07772432B2

Reaction notes

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