tert-Butanol → HCID 59426033, compound

HRID 502173Notes

Reaction equation

HRID 502173 reaction equation
[C:1]([C:3]1[C:11]2[C:6](=[CH:7][C:8]([O:12][CH2:13][CH3:14])=[CH:9][CH:10]=2)[N:5]([CH2:15][CH3:16])[C:4]=1[C:17]1[CH:22]=[CH:21][C:20]([NH:23][C:24](=[O:32])[NH:25][CH2:26][C:27]([O:29]CC)=O)=[CH:19][CH:18]=1)#[N:2].CC(C)([O-])C.[K+].C(O)(C)(C)C>C1COCC1>[O:32]=[C:24]1[NH:25][CH2:26][C:27](=[O:29])[N:23]1[C:20]1[CH:19]=[CH:18][C:17]([C:4]2[N:5]([CH2:15][CH3:16])[C:6]3[C:11]([C:3]=2[C:1]#[N:2])=[CH:10][CH:9]=[C:8]([O:12][CH2:13][CH3:14])[CH:7]=3)=[CH:22][CH:21]=1

Participants

5

Reactant 3

HCID 6386tert-ButanolHCID 23665647Potassium tert-butoxideHCID 59424910HCID 59424910, compound2×

Product 1

HCID 59426033HCID 59426033, compound

Reagents, catalysts & solvents 1

HCID 8028TetrahydrofuranSolvent

Procedure

A solution of ethyl {3-[4-(3-cyano-6-ethoxy-1-ethyl-1H-indol-2-yl)-phenyl]-ureido}-acetate (compound 773, 101 mg, 0.232 mmol) in THF (10 mL) is treated with a solution of potassium tert-butoxide in tert-butanol (0.30 mL, 1.0 M, 0.30 mmol), and the resulting mixture is allowed to stir overnight. The reaction mixture is partitioned between water and ethyl acetate (50 mL each), and the organic phase is washed with saturated brine. The aqueous phases are extracted with more ethyl acetate, and the extracts are combined, dried over anhydrous magnesium sulfate, filtered and evaporated. The residual material is separated by column chromatography (eluting 2/1 ethyl acetate/hexane on silica gel 60) to afford 2-[4-(2,5-dioxo-imidazolidin-1-yl)-phenyl]-6-ethoxy-1-ethyl-1H-indole-3-carbonitrile, compound 779, which is purified farther by trituration with ether, collection by filtration and drying under high vacuum (76 mg, 0.196 mmol, 84%).

Workup

  1. customThe reaction mixture is partitioned between water and ethyl acetate (50 mL each)
  2. washthe organic phase is washed with saturated brine
  3. extractionThe aqueous phases are extracted with more ethyl acetate
  4. dry with materialdried over anhydrous magnesium sulfate
  5. filtrationfiltered
  6. customevaporated
  7. customThe residual material is separated by column chromatography (eluting 2/1 ethyl acetate/hexane on silica gel 60)

Sources & evidence

ORD record
ord-6a8f32e3e9cf4a8db93572417828eb69
Source dataset
uspto-grants-2010_08
Patent number
US07772271B2

Reaction notes

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