Sodium Hydroxide → HCID 18412691, compound

HRID 50218Notes

Reaction equation

HRID 50218 reaction equation
[ClH:1].[C:2]1([N:8]([CH2:32][CH2:33][C:34]([O:36]CC)=[O:35])[C:9]([C:11]2[CH:12]=[CH:13][C:14]3[S:18][C:17]([CH2:19][N:20]([C:22]4[CH:27]=[CH:26][C:25]([C:28](=[NH:30])[NH2:29])=[CH:24][CH:23]=4)[CH3:21])=[N:16][C:15]=3[CH:31]=2)=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1.[OH-].[Na+]>CO>[ClH:1].[C:2]1([N:8]([CH2:32][CH2:33][C:34]([OH:36])=[O:35])[C:9]([C:11]2[CH:12]=[CH:13][C:14]3[S:18][C:17]([CH2:19][N:20]([C:22]4[CH:27]=[CH:26][C:25]([C:28](=[NH:29])[NH2:30])=[CH:24][CH:23]=4)[CH3:21])=[N:16][C:15]=3[CH:31]=2)=[O:10])[CH:7]=[CH:6][CH:5]=[CH:4][CH:3]=1

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 18412339HCID 18412339, compound

Product 1

HCID 18412691HCID 18412691, compoundYield 96%

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Prepared analogously to Example 10 from 2-[N-(4-amidinophenyl)-N-methylaminomethyl]benzothiazol-5-yl-carboxylic acid-N-phenyl-N-(2-ethoxycarbonylethyl)amide hydrochloride and sodium hydroxide solution. Yield: 96% of theory, C26H25N5O3S (487.58); Rf value: 0.48 (Merck RP-8, methanol/5% NaCl solution=6:4); EKA mass spectrum: (M+H)+=488; (M+2Na)++=266.5.

Sources & evidence

ORD record
ord-aa00afb500994ce2bc2d274293fa27bf
Source dataset
uspto-grants-2004_03
Patent number
US06710055B2

Reaction notes

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