反应详情

To a solution of 6-ethoxy-2-(4-nitro-phenyl)-indole-1-carboxylic acid tert-butyl ester (8.1 g, 21.2 mmol) in CH2Cl2 (8 mL) was added TFA (8 mL). This mixture was stirred at room temperature for 2 h and concentrated. The residue was diluted in EtOAc and washed with sat.aq. NaHCO3. The organic layer was concentrated and purified by silica gel chromatography (7:3 CH2Cl2/hexane, followed by 100% CH2Cl2) to provide 6-ethoxy-2-(4-nitro-phenyl)-1H-indole (4.5 g, 68%) as an orange-red solid.

1. concentrationconcentrated
2. additionThe residue was diluted in EtOAc
3. washwashed with sat.aq
4. concentrationThe organic layer was concentrated
5. custompurified by silica gel chromatography (7:3 CH2Cl2/hexane, followed by 100% CH2Cl2)