反应详情

温度

0 °C

To a mixture of 6-ethylsulfanyl-1H-indole (2.75 g, 15.54 mmol) in DMF (20 mL) was added chlorosulfonyl isocyante dropwise at −30° C. The temperature was raised to 0° C. after addition and stirred for 30 minutes. The mixture was partitioned between EtOAc and water. The organic layer was washed with water, brine, dried over Mg2SO4, concentrated and purified on silica gel (CH2Cl2) to provide 6-ethylsulfanyl-1H-indole-3-carbonitrile (3.25 g, 84%) as a white solid.

1. additionwas added chlorosulfonyl isocyante dropwise at −30° C
2. additionafter addition
3. customThe mixture was partitioned between EtOAc and water
4. washThe organic layer was washed with water, brine
5. dry with materialdried over Mg2SO4
6. concentrationconcentrated
7. custompurified on silica gel (CH2Cl2)