反应详情

温度

85 °C

A mixture of 6-ethylsulfanyl-1H-indole-3-carbonitrile (2.13 g, 10.5 mmol) Cs2CO3 (6.9 g, 21 mmol), cyclobutyl bromide (1.78 g, 13.2 mmol) and DMF (20 mL) was heated to 85° C. overnight and, after cooling, partitioned between ethyl acetate and water. The organic layer was washed with water, brine, dried over Mg2SO4, concentrated and purified on silica gel (EtOAc/hexane 5% to 30%) to provide 1-cyclobutyl-6-ethylsulfanyl-1H-indole-3-carbonitrile (2.58 g, 96%) as a light-yellow oil.

1. temperatureafter cooling
2. custompartitioned between ethyl acetate and water
3. washThe organic layer was washed with water, brine
4. dry with materialdried over Mg2SO4
5. concentrationconcentrated
6. custompurified on silica gel (EtOAc/hexane 5% to 30%)