反应详情

1,1-Dioxo-tetrahydrothiopyran-4-ol (1.0 g, 6.6 mmol), pyridine (10 mL), and tosyl chloride (1.6 g, 8.4 mmol) were combined and stirred at room temperature overnight. The reaction mixture was concentrated, diluted in EtOAc and washed with aqueous HCl and brine. The organic layer was dried, concentrated and triturated with hexane to yield O-tosyl-1,1-dioxo-tetrahydrothiopyran-4-ol (1.073 g, 53%) as a white solid.

1. concentrationThe reaction mixture was concentrated
2. additiondiluted in EtOAc
3. washwashed with aqueous HCl and brine
4. customThe organic layer was dried
5. concentrationconcentrated
6. customtriturated with hexane