HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Triethylamine → 1h-Indole-7-carboxylic acid[1-(4-chloro-3-ethoxy-benzyl)piperidin-4-yl]-amide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Triethylamine | HCID 8471 | — |
| Edukt | 1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimide | HCID 15908 | — |
| Edukt | 1H-Indole-7-carboxylic acid | HCID 74281 | — |
| Edukt | 1-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine | HCID 59210377 | — |
| Lösungsmittel | Dimethylformamide | HCID 6228 | — |
| Produkt | 1h-Indole-7-carboxylic acid[1-(4-chloro-3-ethoxy-benzyl)piperidin-4-yl]-amide | HCID 68456899 | 29,1% |
Reaktionsschritte
Indole-7-carboxlic acid (19 mg, 0.12 mmol), Et3N (20 μL, 0.15 mmol), EDCI (25 mg, 0.13 mmol) and 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine (27 mg, 0.1 mmol) were shaken in DMF (1.0 ml) for 16 h, after which time the solvent was evaporated and the residue purified by reversed phase HPLC (MeCN:H2O) affording the title compound (12 mg, 29%). MS: 412.4 (MH+)
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07772253B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-63ae16de5d55451185bbb52acad85966 |
| Quellennotiz | uspto-grants-2010_08 |