4-tert-Butylbenzoic acid → HCID 68455803, compound

HRID 502340Notes

Reaction equation

HRID 502340 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[C:19]([C:23]1[CH:31]=[CH:30][C:26]([C:27](O)=[O:28])=[CH:25][CH:24]=1)([CH3:22])([CH3:21])[CH3:20]>>[C:19]([C:23]1[CH:24]=[CH:25][C:26]([C:27]([NH:13][CH:10]2[CH2:11][CH2:12][N:7]([CH2:6][C:5]3[CH:14]=[CH:15][C:2]([Cl:1])=[C:3]([O:16][CH2:17][CH3:18])[CH:4]=3)[CH2:8][CH2:9]2)=[O:28])=[CH:30][CH:31]=1)([CH3:22])([CH3:20])[CH3:21]

Participants

3

Reactant 2

HCID 74034-tert-Butylbenzoic acidHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68455803HCID 68455803, compoundYield 30%

Procedure

The title compound (13 mg, 30%) was prepared analogously to example 8 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 4-tert-butylbenzoic acid. MS: 429.5 (MH+)

Sources & evidence

ORD record
ord-8d500916186d4d50a65a51d9cb0abf8b
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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