m-Anisoyl chloride → N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-3-methoxy-benzamide

HRID 502344Notes

Reaction equation

HRID 502344 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[CH3:19][O:20][C:21]1[CH:22]=[C:23]([CH:27]=[CH:28][CH:29]=1)[C:24](Cl)=[O:25]>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:24](=[O:25])[C:23]3[CH:27]=[CH:28][CH:29]=[C:21]([O:20][CH3:19])[CH:22]=3)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 74374m-Anisoyl chlorideHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68458065N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-3-methoxy-benzamideYield 65%

Procedure

The title compound (26 mg, 65%) was prepared analogously to example 7 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 3-methoxybenzoyl chloride. MS: 403.4 (MH+).

Sources & evidence

ORD record
ord-313f55fe0e6445b9b117b0ac4215181c
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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