p-Anisoyl chloride → N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-4-methoxy-benzamide

HRID 502347Notes

Reaction equation

HRID 502347 reaction equation
[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH2:13])[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18].[CH3:19][O:20][C:21]1[CH:29]=[CH:28][C:24]([C:25](Cl)=[O:26])=[CH:23][CH:22]=1>>[Cl:1][C:2]1[CH:15]=[CH:14][C:5]([CH2:6][N:7]2[CH2:12][CH2:11][CH:10]([NH:13][C:25](=[O:26])[C:24]3[CH:28]=[CH:29][C:21]([O:20][CH3:19])=[CH:22][CH:23]=3)[CH2:9][CH2:8]2)=[CH:4][C:3]=1[O:16][CH2:17][CH3:18]

Participants

3

Reactant 2

HCID 7477p-Anisoyl chlorideHCID 592103771-(4-Chloro-3-ethoxybenzyl)piperidin-4-ylamine

Product 1

HCID 68454927N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-4-methoxy-benzamideYield 60%

Procedure

The title compound (24 mg, 60%) was prepared analogously to example 7 by coupling of 1-(4-chloro-3-ethoxy-benzyl)piperidin-4-ylamine with 4-methoxybenzoyl chloride. MS: 403.4(MH+).

Sources & evidence

ORD record
ord-3b6c7d153d2e4ea595c917596eff95e9
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

Loading…