Cyclopropanecarbonyl chloride → HCID 68456382, compound

HRID 502376Notes

Reaction equation

[NH2:1][C:2]1[CH:27]=[CH:26][C:5]([C:6]([NH:8][CH:9]2[CH2:14][CH2:13][N:12]([CH2:15][C:16]3[CH:21]=[CH:20][C:19]([Cl:22])=[C:18]([O:23][CH2:24][CH3:25])[CH:17]=3)[CH2:11][CH2:10]2)=[O:7])=[CH:4][N:3]=1.[CH:28]1([C:31](Cl)=[O:32])[CH2:30][CH2:29]1>>[Cl:22][C:19]1[CH:20]=[CH:21][C:16]([CH2:15][N:12]2[CH2:13][CH2:14][CH:9]([NH:8][C:6](=[O:7])[C:5]3[CH:26]=[CH:27][C:2]([NH:1][C:31]([CH:28]4[CH2:30][CH2:29]4)=[O:32])=[N:3][CH:4]=3)[CH2:10][CH2:11]2)=[CH:17][C:18]=1[O:23][CH2:24][CH3:25]

Participants

Reactant 2

HCID 77637Cyclopropanecarbonyl chloride

HCID 68455440HCID 68455440, compound

Product 1

HCID 68456382HCID 68456382, compoundYield 26%

Procedure

The title compound (12 mg, 26%) was prepared analogously to example 7 by coupling of 6-amino-N-[1-(4-chloro-3-ethoxy-benzyl)piperidin-4-yl]-nicotinamide with cyclopropanecarbonyl chloride. MS: 457.4 (MH+).

Sources & evidence

ORD record: ord-0e23e415d7a247a2a168fa7c2c2ab1d4
Source dataset: uspto-grants-2010_08
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07772253B2

Reaction notes

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