HuagongsheHuagongshe Chemistry Print Report · For research reference only
Cyclopropanecarbonyl chloride → N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-5-(cyclopropanecarbonyl-amino)-nicotinamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Cyclopropanecarbonyl chloride | HCID 77637 | — |
| Reactant | 5-Amino-N-[1-(4-chloro-3-ethoxy-benzyl)piperidin-4-yl]-nicotinamide | HCID 68457178 | — |
| Product | N-[1-(4-Chloro-3-ethoxy-benzyl)piperidin-4-yl]-5-(cyclopropanecarbonyl-amino)-nicotinamide | HCID 68458502 | 26% |
Reaction Steps
The title compound (12 mg, 26%) was prepared analogously to example 7 by coupling of 5-amino-N-[1-(4-chloro-3-ethoxy-benzyl)piperidin-4-yl]-nicotinamide with cyclopropanecarbonyl chloride. MS: 457.4 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772253B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-9aefc2780cd8482082d4e6a0af351ed9 |
| Source note | uspto-grants-2010_08 |