反应详情

温度

50 °C

To a solution of (3,5-diethoxy-4-fluoro-phenyl)-methanol (2.30 g, 10.7 mmol, 1.0 eq.) in 1,2-dichloroethane (50 mL) was added MnO2 (2.89 g, 33.3 mmol, 3.1 eq.). The reaction mixture was stirred for 21 h at 50° C. and filtered through Hyflo providing 1.90 g (83%) of the title compound. 1H NMR (400 MHz, CDCl3): δ1.38 (t, J=7.0 Hz, 6H), 4.09 (q, J=7.0 Hz, 4H), 7.04 (d, J=7.2 Hz, 2H), 9.75 (s, 1H). MS: 212.1 (M+).

1. filtrationfiltered through Hyflo