HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 1-Methyl-2-[(4-amidinophenyl)oxymethyl]benzimidazol-5-yl-sulfonic acid-n-methyl-n-(1-methylpiperidin-4-yl)amide hydrochloride
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Ammonium Carbonate | HCID 517111 | — |
| Reactant | HCID 18412364 | HCID 18412364 | — |
| Product | 1-Methyl-2-[(4-amidinophenyl)oxymethyl]benzimidazol-5-yl-sulfonic acid-n-methyl-n-(1-methylpiperidin-4-yl)amide hydrochloride | HCID 18412592 | — |
Reaction Steps
Prepared analogously to Example 25d from 400 mg of 1-methyl-2-[(4-cyanophenyl)oxymethyl]benzimidazol-5-yl-sulfonic acid-N-methyl-N-(1-methylpiperidin-4-yl)amide with ethanolic hydrochloric acid and ammonium carbonate. Yield: 370 mg (83% of theory), C23H30N6O3S (470.6); EKA mass spectrum: (M+H)+=471; (M+2H)++=236.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US06710055B2 |
| Source dataset | uspto-grants-2004_03 |
| ORD ID | ord-6f1f498b56794aa9bdb2f0b37f1daf4d |
| Source note | uspto-grants-2004_03 |