Trifluoroacetic acid → HCID 86609552, compound

HRID 502407Notes

Reaction equation

HRID 502407 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15](=[O:27])[C:16]2[CH:21]=[CH:20][CH:19]=[C:18]([O:22][S:23]([CH3:26])(=[O:25])=[O:24])[CH:17]=2)[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[NH:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:16]2[CH:17]=[C:18]([O:22][S:23]([CH3:26])(=[O:24])=[O:25])[CH:19]=[CH:20][CH:21]=2)=[O:27])[CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 86609551HCID 86609551, compound

Product 1

HCID 86609552HCID 86609552, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The above prepared 4-(3-methanesulfonyloxy-benzoylamino)-piperidine-1-carboxylic acid tert-butyl ester (0.920 g, 1.85 mmol) was dissolved in 9.5 ml of CH2Cl2 and treated with 2.4 ml of trifluoroacetic acid. After stirring for 4 h at ambient temperature, TLC indicated the absence of starting material. Evaporation of all volatiles left 1.47 g of the title compound as trifluoroacetate as off-white viscous oil.

Workup

  1. customEvaporation of all volatiles
  2. waitleft 1.47 g of the title compound as trifluoroacetate as off-white viscous oil

Sources & evidence

ORD record
ord-ce62ddb20bb34041b33516db0a1a9e6e
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

Loading…