HRID50241

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID313

Hydrochloric Acid

ClH

HCID517111

Ammonium carbonate

CH8N2O3

结构：CCOC(=O)CCCN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)nc(COc1ccc(C#N)cc1)n2C

HCID18412355

未命名化合物

PRODUCTS

生成物

结构：CCOC(=O)CCCN(c1ccccc1)S(=O)(=O)c1ccc2c(c1)nc(COc1ccc(C(=N)N)cc1)n2C.Cl

HCID18412649

未命名化合物

收率 57%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

Prepared analogously to Example 32 from 1-methyl-2-[(4-cyanophenyl)oxymethyl]benzimidazol-5-yl-sulfonic acid-N-(3-ethoxycarbonyl-n-propyl)-N-phenylamide, ethanolic hydrochloric acid, ethanol, and ammonium carbonate. Yield: 57% of theory, C28H31N5O5S (549.7); EKA mass spectrum: (M+H)+=550.

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-566c2e6e31c54ff09cf483afad8ca026
来源数据集: uspto-grants-2004_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US06710055B2
来源说明: uspto-grants-2004_03

反应 SMILES

[CH2:1]([O:3][C:4]([CH2:6][CH2:7][CH2:8][N:9]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[S:10]([C:13]1[CH:32]=[CH:31][C:16]2[N:17]([CH3:30])[C:18]([CH2:20][O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28]#[N:29])=[CH:24][CH:23]=3)=[N:19][C:15]=2[CH:14]=1)(=[O:12])=[O:11])=[O:5])[CH3:2].[ClH:39].C(=O)([O-])[O-].[NH4+:44].[NH4+]>C(O)C>[ClH:39].[CH2:1]([O:3][C:4]([CH2:6][CH2:7][CH2:8][N:9]([C:33]1[CH:38]=[CH:37][CH:36]=[CH:35][CH:34]=1)[S:10]([C:13]1[CH:32]=[CH:31][C:16]2[N:17]([CH3:30])[C:18]([CH2:20][O:21][C:22]3[CH:27]=[CH:26][C:25]([C:28](=[NH:44])[NH2:29])=[CH:24][CH:23]=3)=[N:19][C:15]=2[CH:14]=1)(=[O:12])=[O:11])=[O:5])[CH3:2]