Trifluoroacetic acid → HCID 68458546, compound

HRID 502414Notes

Reaction equation

HRID 502414 reaction equation
C(OC([N:8]1[CH2:13][CH2:12][CH:11]([NH:14][C:15]([C:17]2[CH:18]=[N:19][C:20]([N:23](C(OC(C)(C)C)=O)[CH3:24])=[CH:21][CH:22]=2)=[O:16])[CH2:10][CH2:9]1)=O)(C)(C)C.FC(F)(F)C(O)=O>C(Cl)Cl>[CH3:24][NH:23][C:20]1[CH:21]=[CH:22][C:17]([C:15]([NH:14][CH:11]2[CH2:12][CH2:13][NH:8][CH2:9][CH2:10]2)=[O:16])=[CH:18][N:19]=1

Participants

4

Reactant 2

HCID 6422Trifluoroacetic acidHCID 68454645HCID 68454645, compound

Product 1

HCID 68458546HCID 68458546, compound

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

The above prepared 4-{[6-(tert-butoxycarbonyl-methyl-amino)-pyridine-3-carbonyl]-amino}-piperidine-1-carboxylic acid tert-butyl ester (0.495 g, 1.14 mmol) was dissolved in 14 ml of CH2Cl2 and treated with 2.8 ml of trifluoroacetic acid. After stirring for 3 h at ambient temperature, TLC indicated the absence of starting material. Evaporation of all volatiles left 0.704 g of the title compound as trifluoroacetate as light brown amorphous solid.

Workup

  1. customEvaporation of all volatiles
  2. waitleft 0.704 g of the title compound as trifluoroacetate as light brown amorphous solid

Sources & evidence

ORD record
ord-e5f56355b1094423a2a46a20c4c614c7
Source dataset
uspto-grants-2010_08
Patent number
US07772253B2

Reaction notes

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