反应详情

3-Ethoxy-4-fluoro-benzaldehyde (0.081 g, 0.482 mmol) was dissolved in 1 ml of DMSO and treated with potassium carbonate (0.166 g, 2.5 eq.) and imidazole (0.066 g, 2 eq.), and the mixture was allowed to react under a balloon of argon for 2 h at 105° C. Pouring onto crashed ice/NH4Cl, twofold extraction with AcOEt, washing with water, drying over sodium sulfate, and evaporation of the solvents, followed by flash chromatography (silica gel, AcOEt) produced 0.087 g of the title compound as off-white crystals.

1. customto react under a balloon of argon for 2 h at 105° C
2. additionPouring
3. extractionice/NH4Cl, twofold extraction with AcOEt
4. washwashing with water
5. dry with materialdrying over sodium sulfate, and evaporation of the solvents