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Diisopropylethylamine → N-[1-(3,5-Diisopropoxy-benzyl)-piperidin-4-yl]-5-methoxy-isophthalamic acid methyl ester
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Diisopropylethylamine | HCID 81531 | — |
| 反応物 | Sodium cyanoborohydride | HCID 5003444 | — |
| 反応物 | 3,5-diisopropoxybenzaldehyde | HCID 11310605 | — |
| 反応物 | N-[1-(3,5-Diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-5-methoxy-isophthalamic acid methyl ester | HCID 68458070 | — |
| 溶媒 | Acetic Acid | HCID 176 | — |
| 溶媒 | Ethanol | HCID 702 | — |
| 生成物 | N-[1-(3,5-Diisopropoxy-benzyl)-piperidin-4-yl]-5-methoxy-isophthalamic acid methyl ester | HCID 68456062 | — |
反応手順
In analogy to the procedure described in example 50k), 5-methoxy-N-piperidin-4-yl-isophthalamic acid methyl ester (example 143) was reacted with 3,5-diisopropoxy-benzaldehyde (example 126b), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50-C to yield the title compound as colorless oil. MS: 499.3 (MH+).
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US07772253B2 |
| 出典データセット | uspto-grants-2010_08 |
| ORD ID | ord-372fd5b2e2084da480e8eb559dac0645 |
| 出典メモ | uspto-grants-2010_08 |