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HRID502428

反应详情

EQUATION

反应方程式

HRID 502428 的结构方程式

REACTANTS

反应物

4
结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：[BH3-]C#N.[Na+]
HCID5003444

Sodium cyanotrihydroborate

CH3BNNa

结构：CC(C)Oc1cc(C=O)cc(OC(C)C)c1
HCID11310605

3,5-diisopropoxybenzaldehyde

C13H18O3

结构：CCOc1cc(CN2CCC(NC(=O)c3cc(OC)cc(C(=O)OC)c3)CC2)cc(OCC)c1F
HCID68458070

N-[1-(3,5-Diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-5-methoxy-isophthalamic acid methyl ester

C26H33FN2O6

PRODUCTS

生成物

1
结构：COC(=O)c1cc(OC)cc(C(=O)NC2CCN(Cc3cc(OC(C)C)cc(OC(C)C)c3)CC2)c1
HCID68456062

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

2
结构：CC(=O)O
溶剂HCID176

Acetic Acid

C2H4O2

结构：CCO
溶剂HCID702

Ethanol

C2H6O

PROCEDURE

实验过程

In analogy to the procedure described in example 50k), 5-methoxy-N-piperidin-4-yl-isophthalamic acid methyl ester (example 143) was reacted with 3,5-diisopropoxy-benzaldehyde (example 126b), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50-C to yield the title compound as colorless oil. MS: 499.3 (MH+).