Huagongshe화공사 화학 정보 인쇄 보고서 · 연구 참고용
Trifluoroacetic acid → HCID 178466700, 화합물
참여 물질
| 역할 | 이름 | HCID | 투입량 |
|---|---|---|---|
| 반응물 | Trifluoroacetic acid | HCID 6422 | — |
| 반응물 | Diisopropylethylamine | HCID 81531 | — |
| 반응물 | Sodium cyanoborohydride | HCID 5003444 | — |
| 반응물 | 3,5-Diethoxy-4-fluoro-benzaldehyde | HCID 59128273 | — |
| 반응물 | 4-[3-methoxy-5-(1-trityl-1H-tetrazol-5-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 68456484 | — |
| 반응물 | 4-[3-methoxy-5-(2-trityl-2H-tetrazol-5-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester | HCID 68457857 | — |
| 반응물 | HCID 178493414 | HCID 178493414 | — |
| 용매 | Acetic Acid | HCID 176 | — |
| 용매 | Ethanol | HCID 702 | — |
| 용매 | Dichloromethane | HCID 6344 | — |
| 생성물 | HCID 178466700 | HCID 178466700 | — |
반응 단계
In analogy to the procedure described in example 50k), 3-methoxy-N-piperidin-4-yl-5-(1H-tetrazol-5-ylmethoxy)-benzamide [prepared from 4-[3-methoxy-5-(1-trityl-1H-tetrazol-5-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester and/or 4-[3-methoxy-5-(2-trityl-2H-tetrazol-5-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester by reaction with trifluoroacetic acid in dichloromethane in analogy to the procedure described in example 50i)] was reacted with 3,5-diethoxy-4-fluoro-benzaldehyde (example 50 g), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as off-white solid. MS: 529.2 (MH+).
출처 및 근거
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 특허 번호 | US07772253B2 |
| 출처 데이터셋 | uspto-grants-2010_08 |
| ORD ID | ord-c1681fe5717846b1a96f7ca057c07fd9 |
| 출처 메모 | uspto-grants-2010_08 |