反应详情

In analogy to the procedure described in example 50k), 3-methoxy-N-piperidin-4-yl-5-(1H-tetrazol-5-ylmethoxy)-benzamide [prepared from 4-[3-methoxy-5-(1-trityl-1H-tetrazol-5-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester and/or 4-[3-methoxy-5-(2-trityl-2H-tetrazol-5-ylmethoxy)-benzoylamino]-piperidine-1-carboxylic acid tert-butyl ester by reaction with trifluoroacetic acid in dichloromethane in analogy to the procedure described in example 50i)] was reacted with 3,5-diethoxy-4-fluoro-benzaldehyde (example 50 g), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as off-white solid. MS: 529.2 (MH+).