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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 50244Generated: October 31, 2026

N-(4-Cyanophenyl)glycine → 1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(3-tert-butyloxycarbonylpropyl)amide

https://huagongshe.com/reaction/50244

Reaction equation

Participants

RoleNameHCIDCharge
ReactantN-(4-Cyanophenyl)glycineHCID 817965—
ReactantHCID 18412638HCID 18412638—
SolventDichloromethane methanolHCID 21226129—
Product1-methyl-2-[N-(4-cyanophenyl)aminomethyl]benzimidazol-5-yl-carboxylic acid-N-phenyl-N-(3-tert-butyloxycarbonylpropyl)amideHCID 1841243765%

Reaction Steps

Prepared analogously to Example 25c from N-(4-cyanophenyl)glycine and 3-amino-4-methylaminobenzoic acid-N-phenyl-N-(3-tert-butyloxycarbonylpropyl)amide. Yield: 65% of theory; Rf value: 0.17 (silica gel; dichloromethane/methanol=19:1).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS06710055B2
Source datasetuspto-grants-2004_03
ORD IDord-29c85074894544b8bdb20862a3240b3b
Source noteuspto-grants-2004_03