HuagongsheHuagongshe Chemie-Druckbericht · Nur für Forschungszwecke
Diisopropylethylamine → N-[1-(3,5-Diethoxy-4-[1,2,4]triazol-1-yl-benzyl)-piperidin-4-yl]-3-(2H-tetrazol-5-yl)-benzamide
Beteiligte Stoffe
| Rolle | Name | HCID | Einwaage |
|---|---|---|---|
| Edukt | Diisopropylethylamine | HCID 81531 | — |
| Edukt | Sodium cyanoborohydride | HCID 5003444 | — |
| Edukt | 3,5-Diethoxy-4-[1,2,4]triazol-1-yl-benzaldehyde | HCID 58706331 | — |
| Edukt | N-[1-(3,5-Diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-3-(2H-tetrazol-5-yl)-benzamide | HCID 68456697 | — |
| Lösungsmittel | Acetic Acid | HCID 176 | — |
| Lösungsmittel | Ethanol | HCID 702 | — |
| Produkt | N-[1-(3,5-Diethoxy-4-[1,2,4]triazol-1-yl-benzyl)-piperidin-4-yl]-3-(2H-tetrazol-5-yl)-benzamide | HCID 68455412 | — |
Reaktionsschritte
In analogy to the procedure described in example 50k), N-piperidin-4-yl-3-(1H-tetrazol-5-yl)-benzamide (example 178) was reacted with 3,5-diethoxy-4-[1,2,4]triazol-1-yl-benzaldehyde (example 129a), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as light yellow solid. MS: 518.2 (MH+).
Herkunft & Nachweise
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patentnummer | US07772253B2 |
| Quelldatensatz | uspto-grants-2010_08 |
| ORD ID | ord-ee97e74fa2494fa09b6556b0ababb064 |
| Quellennotiz | uspto-grants-2010_08 |