HuagongsheHuagongshe Chemistry Print Report · For research reference only
Diisopropylethylamine → N-[1-(3,5-Diisopropoxy-benzoyl)-piperidin-4-yl]-3-hydroxymethyl-5-methoxy-benzamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Diisopropylethylamine | HCID 81531 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 3,5-diisopropoxybenzaldehyde | HCID 11310605 | — |
| Reactant | N-[1-(3,5-Diethoxy-4-fluoro-benzyl)-piperidin-4-yl]-3-hydroxymethyl-5-methoxy-benzamide | HCID 68458782 | — |
| Solvent | Acetic Acid | HCID 176 | — |
| Solvent | Ethanol | HCID 702 | — |
| Product | N-[1-(3,5-Diisopropoxy-benzoyl)-piperidin-4-yl]-3-hydroxymethyl-5-methoxy-benzamide | HCID 68455452 | — |
Reaction Steps
In analogy to the procedure described in example 50k), 3-hydroxymethyl-5-methoxy-N-piperidin-4-yl-benzamide (example 217) was reacted with 3,5-diisopropoxy-benzaldehyde (example 126b), sodium cyanoborohydride, N-ethyl-diisopropylamine and acetic acid in ethanol at 50° C. to yield the title compound as colorless solid. MS: 471.1 (MH+).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07772253B2 |
| Source dataset | uspto-grants-2010_08 |
| ORD ID | ord-9fb1a1380fcc444eadcfea9f1f75b259 |
| Source note | uspto-grants-2010_08 |